HUMANIN

Humanin is a remarkable mitochondrial-derived peptide with powerful anti-aging, neuroprotective, and metabolic benefits. It helps protect cells from oxidative stress, promotes cell survival, and supports healthy mitochondrial function. Humanin has shown promise in improving insulin sensitivity, reducing inflammation, and defending against neurodegenerative diseases like Alzheimer’s. It also enhances cardiovascular health and may delay age-related decline in both the brain and body. By activating cellular defense pathways and reducing apoptosis (cell death), Humanin supports longevity and resilience under physical or metabolic stress. It's an exciting peptide in the field of longevity and cellular protection for healthy aging.

Benefits

Neuroprotective Benefits

Protects neurons from oxidative stress and cell death
Reduces risk and progression of Alzheimer’s disease and other neurodegenerative conditions
Improves memory, cognitive function, and mental clarity

Cellular Protection & Longevity

Inhibits apoptosis (programmed cell death)
Enhances mitochondrial health and cellular stress resistance
Activates longevity genes and supports healthy aging

Metabolic & Hormonal Support

Improves insulin sensitivity and glucose metabolism
May help prevent or manage type 2 diabetes
Reduces inflammatory markers and oxidative stress

Cardiovascular Health

Protects heart tissue from ischemic damage
Improves vascular function and reduces inflammation in blood vessels

Additional Benefits

Enhances resilience under physical or metabolic stress
May reduce signs of age-related decline in various organs
Supports overall vitality and healthspan extension

Side Effects

Commonly Reported (Mild and Rare):

Injection site irritation (redness, swelling, or mild discomfort)
Fatigue or mild tiredness shortly after dosing
Headache
Mild dizziness or lightheadedness
Nausea (rare)

Unconfirmed or Theoretical Risks:

Hormonal interaction (due to impact on insulin signaling and apoptosis pathways)
Unknown long-term effects, as human trials are limited
Possible immune modulation (beneficial or adverse, depending on individual)

Important Notes:

No major adverse effects have been reported in preclinical or early clinical trials
Start with low doses and monitor response
Should be used under medical supervision, especially when combined with other peptides or therapies

Dosages

Standard Dosage (Subcutaneous Injection):

Dose: 1 mg to 10 mg per injection
Frequency: 2–3 times per week (for general longevity and neuroprotection)
Cycle Duration: 4–8 weeks, with optional breaks
Route: Subcutaneous (abdomen, thigh, or upper arm)

High-Intensity Protocol (For Cognitive or Metabolic Support):

Dose: 5 mg daily
Frequency: 5 days per week for 2–4 weeks
May be followed by a lower-dose maintenance protocol

Reconstitution & Storage:

Reconstitute with bacteriostatic water
Store in the refrigerator (2–8°C) after mixing
Typical reconstitution: 10 mg vial + 1 mL = 1 mg per 0.1 mL

Best Practices:

Take in the morning or midday to avoid sleep disruption
Can be stacked with MOTS-c, NAD+, or 5-Amino-1MQ for enhanced metabolic and longevity effects
Monitor energy, cognitive function, and metabolic markers to fine-tune dosing

Note: Humanin is still in the experimental phase and not MHRA-approved. These recommendations are based on animal studies, early human data, and practitioner experience. Always consult a healthcare provider before starting peptide therapy.

Medical Disclaimer: These guidelines are for educational purposes only. Always consult a licensed medical professional before starting any peptide therapy.