top of page

TRIPEPTIDE-1
(glycine, histidine, and lysine)

Tripeptide-1, also known as GHK (glycyl-histidyl-lysine), is a powerful skin-regenerating peptide with remarkable anti-aging and healing properties. It stimulates collagen and glycosaminoglycan synthesis, improving skin firmness, elasticity, and smoothness. Tripeptide-1 also enhances wound healing, reduces inflammation, and supports the skin’s natural barrier function. It helps repair UV damage, reduces fine lines, and improves overall skin tone and texture. When combined with copper (GHK-Cu), its effects are even more potent, promoting skin regeneration and youthful radiance. Safe for all skin types, Tripeptide-1 is a key ingredient in advanced skincare formulations aimed at reversing signs of aging and enhancing skin vitality.

Benefits

Stimulates Collagen Production
​

  • Boosts types I and III collagen, leading to firmer, more youthful skin

 
Enhances Skin Elasticity and Firmness
​

  • Improves structural proteins like elastin and glycosaminoglycans (e.g., hyaluronic acid)

 
Accelerates Wound Healing
​

  • Promotes tissue repair and regeneration of damaged or aging skin

 
Improves Skin Texture and Tone
​

  • Smooths roughness and uneven skin tone for a more radiant appearance

 
Reduces Fine Lines and Wrinkles
​

  • Softens visible signs of aging by restoring skin volume and resilience

 
Strengthens the Skin Barrier
​

  • Enhances skin’s protective function and hydration retention

 
Fights Inflammation and Redness
​

  • Calms irritated or stressed skin, especially after treatments

 
Repairs Sun and UV Damage
​

  • Supports DNA repair enzymes and reduces photodamage

 
Antioxidant Protection
​

  • Neutralizes free radicals and reduces oxidative stress

 
Synergizes with Copper (GHK-Cu)
​

  • When bonded with copper, effects on healing, anti-aging, and cellular repair are amplified

Side Effects

Mild Skin Irritation
​

  • Redness, itching, or stinging—especially with high concentrations or in sensitive skin

 
Breakouts or Congestion
​

  • In rare cases, especially in acne-prone skin, heavy formulations containing GHK-Cu may clog pores

 
Allergic Reaction (Rare)
​

  • Swelling, rash, or sensitivity to the peptide or base ingredients

 
Copper Sensitivity (GHK-Cu only)
​

  • Overuse may theoretically affect copper balance in the body, though this is extremely rare with topical application

  • Discoloration or temporary bluish tint on skin if the concentration is too high

 
Product Instability
​

  • Poorly formulated products may degrade quickly, reducing efficacy and increasing the risk of irritation

 
How to Minimize Risks
​

  • Patch test before full use

  • Use within recommended concentrations (typically 0.05%–0.5%)

  • Avoid combining with strong acids or retinoids unless tolerated well

  • Store in a cool, dark place to preserve stability

Dosage

Common Injectable Dosage (Subcutaneous or Intradermal Use):
​

  • Daily dose: 100–200 mcg per injection

  • Frequency: Once daily or every other day

  • Cycle length: 2–4 weeks, followed by a break

 
Injection Sites
​

  • Subcutaneous (fatty tissue) areas like:

    • Abdomen

    • Upper thigh

    • Around areas of skin damage or cosmetic concern (if intradermal)

 

Tips:

  • Store peptide in the refrigerator (2–8°C) once reconstituted.

  • Use bacteriostatic water for reconstitution.

  • Always follow aseptic injection protocols.​

 

Medical Disclaimer: These guidelines are for educational purposes only. Always consult a licensed medical professional before starting any peptide therapy.

  • Instagram
  • Twitter
© 2025 thepeptide.guide
bottom of page