MOTS-C

MOTS-c is a mitochondrial-derived peptide that plays a powerful role in enhancing cellular energy, metabolic function, and longevity. It improves insulin sensitivity, boosts glucose metabolism, and supports fat loss by activating AMPK, the body’s energy regulator. MOTS-c also enhances mitochondrial function, making it ideal for improving endurance, reducing fatigue, and promoting resilience under physical or metabolic stress. It has shown promise in anti-aging, weight management, and protecting against metabolic disorders. By optimizing how cells use fuel, MOTS-c helps the body perform better, recover faster, and age more gracefully—making it a cutting-edge peptide for healthspan and performance enhancement.

Benefits

Cellular Energy & Metabolic Health

Enhances mitochondrial function and energy production (ATP)
Activates AMPK, improving cellular fuel efficiency
Improves glucose metabolism and insulin sensitivity
Aids in fat loss and weight management

Anti-Aging & Longevity

Promotes healthy aging by supporting metabolic resilience
Reduces oxidative stress and inflammation
May extend healthspan and mitochondrial vitality
Shown to protect against age-related metabolic decline

Performance & Physical Resilience

Boosts endurance and physical performance
Reduces fatigue and improves recovery
Enhances the body’s ability to adapt to metabolic or oxidative stress

Additional Benefits

Supports cognitive clarity and neuroprotection
May help prevent or manage type 2 diabetes
Encourages cellular homeostasis and DNA repair
Complements other peptides like 5-Amino-1MQ, GHK-Cu, and NAD+

Side Effects

Commonly Reported (Rare and Mild):

Injection site irritation (redness, swelling, or discomfort)
Mild headache
Fatigue (usually temporary)
Dizziness or lightheadedness (especially if dehydrated)
Nausea (in some sensitive individuals)

Less Common or Theoretical Risks:

Temporary blood sugar drop (due to improved insulin sensitivity)
Mild joint or muscle discomfort (rare)
Sleep disturbances if taken too late in the day (due to increased energy)

Important Notes:

No major adverse effects reported in available preclinical or early clinical data
Long-term safety in humans is still under investigation
Best used under medical supervision, especially for individuals with metabolic or mitochondrial conditions

Dosages

Standard Dosage (Subcutaneous Injection):

Dosage: 5 mg per injection
Frequency: 2–3 times per week for general wellness or daily for short-term metabolic or performance goals
Cycle Duration: 4 to 8 weeks
Rest Period: Optional 2–4 week break between cycles

Athletic or Performance Optimisation:

Dose: 5–10 mg per day
Frequency: Daily for 7–10 days leading up to or during intense physical activity or training
Purpose: Boosts endurance, mitochondrial efficiency, and metabolic resilience

Administration Guidelines:

Route: Subcutaneous injection (abdomen or thigh)
Reconstitution: Typically with bacteriostatic water (e.g., 1 mL for a 10 mg vial = 1 mg per 0.1 mL)
Storage: Refrigerate after reconstitution

Tips:

Best taken in the morning to avoid sleep disruption
Stack well with 5-Amino-1MQ, NAD+, or CJC-1295 for enhanced metabolic and anti-aging effects
Stay hydrated and monitor for any blood sugar fluctuations if sensitive

Medical Disclaimer: These guidelines are for educational purposes only. Always consult a licensed medical professional before starting any peptide therapy.